A cost-effectiveness comparison of liquor carbonis distillate solution and calcipotriol cream in the treatment of moderate chronic plaque psoriasis.
نویسندگان
چکیده
be no personal or family history of typical chronic plaque psoriasis lesionselsewhereonthebody,nohistoryofatopic dermatitis, and no relevant positive findings on patch testing. Patients were considered to have palmoplantar psoriasis if they presented with well-demarcated, symmetric, indurated, and hyperkeratotic plaques on the palms with asharpcutoff at thewrist.Patientswereconsidered tohave typical chronic plaque psoriasis if lesions were distributed on the extensor elbows, knees, scalp, nails, or trunk. All patients had chronic disease present for at least 6 months and all had not had topical therapy for at least 2 weeks and systemic therapy for at least 4 weeks. Tissue samples were obtained by 4-mm punch biopsy specimens taken from lesional skin of patients with HHD (n=4), palmoplantar psoriasis (n=4), and chronic plaque psoriasis (n=6) and nonlesional skin of patients with psoriasis(n=6).Frozentissuesectionswereprepared,andslides were incubated in 10% methanol for 10 minutes, in 3% hydrogen peroxide for 10 minutes, and then in blocking solution for 1 hour. Antibodies directed against human IL-23 (Biolegend,SanDiego,California)werethenappliedataconcentration of 1:50 overnight at 4°C. Vectastain Elite ABCPeroxidasekitsandVectorVIPperoxidasesubstratekits(Vector Laboratories, Burlingame, California) were used for visualizingcells.Positivecellswerecountedin8high-power fields, and the average number of labeled cells was calculated.A1-way,between-subjectanalysisofvariancewasconducted to compare the expression level of IL-23 in the 4 groups. A paired t test was used in post hoc analysis to individuallycompareeachofthe4groupsagainstoneanother.
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ورودعنوان ژورنال:
- Archives of dermatology
دوره 146 8 شماره
صفحات -
تاریخ انتشار 2010